ADVERTISEMENT

Mineral · in-depth review

Copper

Copper

Copper is a cofactor for ceruloplasmin, cytochrome c oxidase, and lysyl oxidase, linking iron transport, energy production, and connective-tissue cross-linking.

Also known asCuElemental Copper
Related diseasesIron-deficiency anaemia

Marked asPrimarySupporting

Primary

Supports iron transport and blood formation

Ceruloplasmin oxidizes ferrous iron to ferric iron before it can be handed to transferrin for marrow hematopoiesis; when copper is short, iron is hard to mobilize. Organ meats, oysters, and nuts are food copper sources; iron and copper must both be adequate on the hematopoietic chain, and shortness of breath after activity and fatigue often appear together.

Primary

Supports collagen cross-linking and connective tissue

Lysyl oxidase uses copper as a cofactor to cross-link collagen and elastin; strength of vessel walls and bone matrix depends on this step. Hair and skin pigment enzymes also contain copper; liver and whole grains are steady sources, and skin and hair pigment also depend on copper enzymes.

Primary

Supports cellular respiratory energy production

Cytochrome c oxidase hands electrons to oxygen at the end of the respiratory chain; this step needs copper. When daytime fatigue and tissue energy use rise, whether copper respiratory enzymes are adequate is asked most often; brain development also depends on this energy path, and daytime fatigue is the felt effect asked about most often.

ADVERTISEMENT

Slow wound healing

Lysyl oxidase uses copper as a cofactor to cross-link collagen and elastin; strength of vessel walls and bone matrix depends on this step. Hair and skin pigment enzymes also contain copper; liver and whole grains are steady sources, and skin and hair pigment also depend on copper enzymes. People whose small cuts crust slowly and keep splitting more often notice healing speed and a smoother scar surface after several continuous weeks.

Fatigue

Ceruloplasmin oxidizes ferrous iron to ferric iron before it can be handed to transferrin for marrow hematopoiesis; when copper is short, iron is hard to mobilize. Organ meats, oysters, and nuts are food copper sources; iron and copper must both be adequate on the hematopoietic chain, and shortness of breath after activity and fatigue often appear together. People who cannot get going by day and feel foggy in the afternoon more often notice stamina for tasks and mental freshness after several continuous weeks.

Iron-deficiency anaemia

Ceruloplasmin oxidizes ferrous iron to ferric iron before it can be handed to transferrin for marrow hematopoiesis; when copper is short, iron is hard to mobilize. Organ meats, oysters, and nuts are food copper sources; iron and copper must both be adequate on the hematopoietic chain, and shortness of breath after activity and fatigue often appear together. People who look pale and get short of breath on stairs, already tracking haemoglobin, more often notice spirits and labs after several continuous weeks.

With foodBest taken with food
Best timeMorning or midday
SolubilityWater-soluble

Note that zinc supplements may affect copper status.

General wellnessAdults 900 mcg/day
Specific needsTreatment doses for deficiency must be set by a doctor from blood tests. The adult upper limit is 10,000 mcg/day.

How oftenSupplement only when diet is inadequate or there is a medical need.

Cautions

People with liver disease, Wilson disease, or long-term high zinc intake should ask a clinician first.

Both copper deficiency and excess can affect blood and nerves.

Interactions

  1. High-dose zinc (antagonizes copper absorption)
Common side effects

· Nausea

· Stomach discomfort

Rare but important

· Long-term excess can cause liver damage.

Long-term dependenceNot addictive; long-term excess carries a risk of accumulated toxicity.

Sources

These are institution pages you can check—not a certification of this ingredient.

Medical disclaimerThis page is compiled by the HerbBB editorial team for general health information only. It is not a substitute for advice from a doctor, pharmacist, or other qualified clinician. If you have a health condition, take medicines, or are pregnant or breastfeeding, speak with a professional first.