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Vitamin · in-depth review

Pyridoxine Hydrochloride

Pyridoxine Hydrochloride

Pyridoxine hydrochloride is the B6 salt most used in supplements. It is stable and low-cost; the body likewise phosphorylates it to pyridoxal phosphate.

Also known asNo common aliases yet

Marked asPrimarySupporting

Primary

Support amino-acid transamination

The hydrochloride lets pyridoxine crystallize and tablet easily. After absorption it takes the same phosphorylation path as pyridoxine so transaminases have coenzyme. B-complex and single-ingredient tablets are almost all this salt. People who eat little chicken, fish, potato, or banana and have recurring stomatitis use this salt to put B6 alcohol into tablets.

Supporting

Promotes blood formation

Once activated to pyridoxal phosphate, the first step of heme synthesis needs it for δ-aminolevulinic acid formation. The hydrochloride makes pyridoxine a salt that stores well. People who long eat only refined starch with little meat or potato can see fatigue and stomatitis appear together with this hematopoietic coenzyme.

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PMS symptoms

The hydrochloride lets pyridoxine crystallize and tablet easily. People with breast fullness and a shorter temper before menses more often notice swelling-pain and mood swings after several continuous weeks.

Nausea

The hydrochloride lets pyridoxine crystallize and tablet easily. People who feel the stomach turn at cooking smells or in the morning more often notice fewer nauseous spells and better meal tolerance after several continuous weeks.

Low mood

The hydrochloride lets pyridoxine crystallize and tablet easily. People who cannot get going and feel less interest in usual likes more often notice mood-scale scores and daytime interest after several continuous weeks.

Premenstrual syndrome

The hydrochloride lets pyridoxine crystallize and tablet easily. People whose premenstrual mood and swelling already affect work more often notice symptom intensity and number of days after several continuous weeks.

Peripheral neuropathy

The hydrochloride lets pyridoxine crystallize and tablet easily. People with tingling or numbness in fingertips and soles more often notice the area of the feeling and night-time intrusion after several continuous weeks.

With foodMay be taken with breakfast or lunch; if your stomach is sensitive, switch to after a meal. Fat-soluble vitamins are better with fat-containing food; water-soluble vitamins can usually be taken on an empty stomach or with food
Best timeMorning or midday
SolubilityWater-soluble

If numbness or tingling persists, stop raising the dose on your own and see a doctor.

General wellnessAdults 1.3 mg/day (ages 19–50); men 51 and older 1.7 mg/day, women 1.5 mg/day
Specific needsTreatment doses for deficiency must be set by a doctor. The adult supplement upper limit is about 100 mg/day; do not exceed it on your own for long periods.

How oftenCan be used daily, but count the total from all multivitamins.

Cautions

Long-term high doses can cause peripheral neuropathy; do not exceed product or clinician guidance.

Interactions

  1. Levodopa without a decarboxylase inhibitor may be antagonized by pyridoxine
  2. Antiepileptic drugs (may change vitamin B6 status)
Common side effects

· Nausea or stomach upset (high doses)

Rare but important

· Numbness or tingling in the hands or feet, or unsteady walking, may signal neurotoxicity.

Long-term dependenceNot addictive; long-term excess can cause irreversible nerve damage.

Sources

These are institution pages you can check—not a certification of this ingredient.

Medical disclaimerThis page is compiled by the HerbBB editorial team for general health information only. It is not a substitute for advice from a doctor, pharmacist, or other qualified clinician. If you have a health condition, take medicines, or are pregnant or breastfeeding, speak with a professional first.