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Hormone-like · in-depth review

Melatonin

Melatonin

Melatonin is an indoleamine the pineal gland secretes in darkness. It sends the night signal to the body clock, used to shorten sleep-onset time and help align circadian phase across time zones.

Also known asNo common aliases yet
Related diseasesInsomnia disorder
Related symptomsDifficulty falling asleepJet lag

Marked asPrimarySupporting

Primary

Shortens time needed to fall asleep

Exogenous melatonin mimics the pineal rise in darkness; most trials watch sleep-onset time shorten. People on shift work, with overly bright night light, or with delayed sleep onset most often match this signal through falling asleep faster and waking less at night.

Primary

Support jet-lag phase adjustment

Across time zones or shift work, exogenous melatonin pulls clock phase toward night in the target zone. People on long-haul flights and night work most often judge whether phase has aligned from sleep-onset timing, daytime alertness, and whether local routines can be kept.

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With foodCan be taken on an empty stomach or after a light meal
Best time30–60 minutes before bed (for sleep support)
SolubilityFat-soluble, Water-dispersible

After continued use, reassess by how you feel and whether you still need it.

General wellnessTypical daily intake for general wellness: start at 0.3–1 mg; often 1–3 mg, 30–60 minutes before bed
Specific needsTypical adult daily safety upper limit is about 10 mg; jet lag may be a short-term use, still do not exceed this long term.

How oftenUsually fine to use daily; adjust to personal need.

Cautions

Pregnancy, breastfeeding, bleeding tendency, or medicines: ask a clinician before use.

Interactions

  1. Sedatives, benzodiazepines, or alcohol
  2. Anticoagulants
  3. Blood-pressure drugs, immunosuppressants, glucose-lowering drugs
Common side effects

· Some people may notice mild digestive or other discomfort.

Rare but important

· If discomfort persists or you worry about drug interactions, seek professional advice.

Long-term dependenceNo typical addiction evidence; do not exceed labeled amounts on your own long term.

Sources

These are institution pages you can check—not a certification of this ingredient.

Medical disclaimerThis page is compiled by the HerbBB editorial team for general health information only. It is not a substitute for advice from a doctor, pharmacist, or other qualified clinician. If you have a health condition, take medicines, or are pregnant or breastfeeding, speak with a professional first.