Diseases of the musculoskeletal system or connective tissue01
Why supplement?
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Supports metabolic enzymes
Manganese is a cofactor for many metabolic enzymes and manganese superoxide dismutase.
Mechanism: Established✓
Involved in bone formation
Manganese is involved in reactions related to bone and connective-tissue formation.
Nutrition consensus: EstablishedADVERTISEMENT
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How to take it
With foodWith food
Best timeAnytime
High-dose manganese is not recommended for general wellness.
General wellness2.3 mg/day for adult men; 1.8 mg/day for adult women (AI)
Specific needsDeficiency treatment must be decided by a doctor; the adult upper limit is 11 mg/day.
How oftenRely on food first; use supplements only when there is a clear need.
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What to watch
Cautions
High long-term doses can be neurotoxic; people with liver disease may clear it less well.
Iron shortage can raise manganese absorption; review overall nutrition before supplementing.
Common side effects
· Stomach discomfort (high doses)
Rare but important
· Long-term excess may cause Parkinson-like neurologic symptoms.
Long-term dependenceNot addictive; long-term excess can accumulate and harm the nervous system.