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Amino acid · in-depth review

L-Proline

L-Proline

L-proline carries a pyrrolidine ring. The Gly-Pro-Hyp repeats of the collagen triple helix rely on it to bend and stay stable. It is used for wound and connective-tissue repair.

Also known asProline
Related diseasesOsteoarthritis
Related symptomsWrinklesJoint pain

Marked asPrimarySupporting

Primary

Supports wound and skin repair

Collagen α chains repeat a glycine-proline-hydroxyproline motif; proline's pyrrolidine ring lets the triple helix bend and stay stable, and hydroxylation needs vitamin C. Demand for it rises when wounds, tendon, and skin are repairing; broths of skin, sinew, and trotters are also often used to supply this kind of raw material.

Primary

Maintains connective-tissue strength

Fibroblasts take up large amounts of proline when they make collagen; cells can also use it as an osmoprotectant. For people whose tendons tighten after long standing or who are in a skin-repair phase, connective-tissue foods such as skin, sinew, and trotters release large amounts of proline after hydrolysis for collagen to use.

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With foodDepending on the product form, it may be taken with food or after a meal
Best timeMorning or midday, mainly
SolubilityWater-soluble

After continued use, reassess by how you feel and whether you still need it.

General wellnessTypical daily intake for general wellness: often 500–2,000 mg
Specific needsTypical adult daily safety upper limit is about 3,000 mg; do not exceed this on your own long term.

How oftenUsually fine to use daily; adjust to personal need.

Cautions

If you take medicines, are pregnant, or have a chronic condition, ask a clinician before use.

Interactions

  1. Public monographs do not list a clear drug conflict; people on medicines should still ask a clinician first
Common side effects

· Some people may notice mild digestive or other discomfort.

Rare but important

· If discomfort persists or you worry about drug interactions, seek professional advice.

Long-term dependenceNo typical addiction evidence; do not exceed labeled amounts on your own long term.

Sources

These are institution pages you can check—not a certification of this ingredient.

Medical disclaimerThis page is compiled by the HerbBB editorial team for general health information only. It is not a substitute for advice from a doctor, pharmacist, or other qualified clinician. If you have a health condition, take medicines, or are pregnant or breastfeeding, speak with a professional first.